Treatment of liposarcoma in Germany
Modern approaches to the treatment of malignant tumors of adipose tissue
Liposarcoma is a rare malignant tumor arising from fat cells. RheinRegio Klinik Zentrum uses individualized treatment protocols, including radical surgery, modern methods of radiation therapy and targeted drugs. Our goal is to maximize the preservation of the function of the affected area while completely removing the tumor.
Symptoms of liposarcoma
Characteristic manifestations
- Painless mass formation in soft tissues
- Rapid tumor growth (5+ cm increase in 6 months)
- Thick consistency upon palpation
- Restricted mobility when located near joints
Localization
- Hip (40% of cases)
- Retroperitoneal space (20%)
- Shoulder, torso
Important: In 30% of cases, liposarcoma is mistaken for a benign lipoma.
Diagnosis of liposarcoma at RheinRegio Klinik Zentrum
At RheinRegio Klinik Zentrum we carry out:
- MRI with contrast (assessment of relationships with blood vessels and nerves)
- PET-CT (detection of metastases)
- Trephine biopsy under ultrasound control
- Molecular genetic tests:
- FUS-DDIT3 translocation (for myxoid forms)
- MDM2 amplification (differential diagnosis)
Innovation: Intraoperative radiotherapy (IOR) to reduce the risk of relapse.
Each direction is supervised by advanced oncologists.
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Classification and stages of liposarcoma
Histological types
- Highly differentiated (least aggressive)
- Myxoid (intermediate malignancy)
- Pleomorphic (most aggressive)
AJCC Stages
- I: Low-grade tumors <5 cm
- III: High-grade tumors >10 cm
- IV: Presence of distant metastases
Treatment methods for liposarcoma
1. Surgical treatment
- Wide excision involving 2-3 cm of healthy tissue
- Saving operations with microsurgical reconstruction
- Lymph dissection (if nodes are affected)
2. Radiation therapy
- Neoadjuvant (to reduce tumor volume)
- Proton therapy (for retroperitoneal locations)
3. Systemic therapy
- Doxorubicin (first-line drug)
- Trabectedin (for myxoid forms)
- Olaratumab (targeted drug)
Survival prognosis
Highly differentiated forms: 80-90%
Pleomorphic forms: 30-50%
Conclusion: Our clinic uses a personalized approach to each patient with liposarcoma.
Schedule a consultation to develop a personalized treatment plan.
Our clinics
The association of clinics RheinRegio Klinik Zentrum offers the organization of liposarcoma treatment in Germany without intermediaries, providing access to the country’s leading oncology clinics. We combine advanced techniques, an individual approach and the highest level of medical care, giving hope even in difficult cases.
Why RheinRegio Klinik Zentrum?
- Center for Sarcoma Surgery – performs 50+ operations annually
- Interdisciplinary council – oncologists, surgeons, radiologists
- Clinical trials – access to new drugs
- Rehabilitation – restoration of limb function
