Treatment of anal carcinoma in Germany
Modern standards of therapy with preservation of the sphincter apparatus

Anal carcinoma is a rare malignant tumor of the anal canal that requires a comprehensive approach. RheinRegio Klinik Zentrum uses organ-preserving techniques, including chemoradiotherapy according to the Nigro protocol, which allows 80% of patients to avoid a calostomy. Our goal is radical treatment while maintaining quality of life.
Symptoms of Anal Carcinoma
Early signs
- Bloody discharge from the anus
- Foreign body sensation
- Itching and discomfort
Late manifestations
- Intense pelvic pain
- Defecation disorder
- Enlarged inguinal lymph nodes
Important: 30% of cases are misdiagnosed as hemorrhoids.
Diagnosis of anal carcinoma at the RheinRegio Klinik Zentrum
At RheinRegio Klinik Zentrum we carry out:
- High-resolution anoscopy with biopsy
- MRI of the pelvis (assessment of depth of invasion)
- PET-CT for staging
- HPV test (prognostic factor)
- Genetic testing (MSI status)
Innovation: Fluorescent lymphography to detect micrometastases.
Each direction is supervised by advanced oncologists.
Find out the cost of treatment
To find out the approximate cost of treatment, answer a few questions and we will contact you!
Treatment Methods for Anal Carcinoma
1. Chemoradiation therapy
- Nigro Protocol (5-FU + mitomycin + 45 Gy)
- IMRT (gentle irradiation)
2. Surgery
- Local excision (for T1N0)
- Abdominoperineal resection (rare)
3. Immunotherapy
- Pembrolizumab (for MSI-H)
Survival prognosis
- Stage I: 90%
- Stage III: 60%
Make an appointment with a proctologist-oncologist.
Why RheinRegio Klinik Zentrum?

- Accurate diagnosis using 3.0T MRI
- Organ-preserving approach in 85% of cases
- Individual rehabilitation programs












