Treatment of cervical cancer in Germany
Modern methods of treating cervical cancer: from early diagnosis to personalized therapy
Cervical cancer (CC) ranks 4th among cancer diseases in women. RheinRegio Klinik Zentrum uses personalized protocols using organ-preserving techniques in the early stages and combined approaches in advanced forms, which allows achieving a 5-year survival rate of up to 92% with timely treatment.
Symptoms of cervical cancer
Early signs (often absent)
- Contact bleeding
- Copious leucorrhoea with an unpleasant odor
- Discomfort during sexual intercourse
Late symptoms
- Acyclic bleeding
- Pelvic pain
- Swelling of the legs (with metastases to the lymph nodes)
- Hematuria (with damage to the bladder)
Diagnostic methods in Germany
- Advanced colposcopy with 3D visualization
- Liquid PAP test (ThinPrep)
- HPV typing (determination of 14 oncogenic types)
- MRI of the pelvis with diffusion-weighted sequences
- PET-CT (if metastases are suspected)
Diagnosis of cervical cancer at RheinRegio Klinik Zentrum
In our clinic we use modern and accurate methods detecting cervical cancer in the early stages:
Screening and primary diagnosis
- Extended colposcopy – examination of the cervix under magnification with the Lugol test and acetic acid
- PAP test (liquid cytology) – identification of atypical cells
- HPV testing – determination of oncogenic types of virus (16, 18, 31, 33, etc.)
In-depth diagnostics
- Cervical biopsy (puncture, conization) with histological examination
- Immunohistochemistry (determination of p16, Ki-67, PD-L1)
- Molecular genetic tests (for adenocarcinoma)
Visualization
- Ultrasound of the pelvic organs (transvaginal)
- MRI of the pelvis – assessment of tumor extent
- PET-CT – detection of metastases (if stage III-IV is suspected)
Additional Research
- Cystoscopy/rectoscopy (if growth into the bladder/intestines is suspected)
- Tumor markers (SCC, CA 125)
Advantages of RheinRegio Klinik Zentrum:
- High-precision expert-class equipment
- Fast turnaround time for results
- Individual approach to each patient
To make an appointment for diagnostics, contact our specialist!
Each direction is supervised by advanced oncologists.
Find out the cost of treatment
To find out the approximate cost of treatment, answer a few questions and we will contact you!
Classification and stages of cervical cancer
Tumor types:
- Squamous (80-90%)
- Adenocarcinoma (10-20%)
- Rare forms (clear cell, neuroendocrine)
Stages (FIGO 2018):
- I – Limited by the cervix
- IA1-IA2 – microinvasion
- IB1-IB3 – visible tumor (up to 4 cm or more)
- II – Spread beyond the neck:
- IIA – vagina
- IIB – parametrium
- III – Up to the walls of the pelvis/lower third of the vagina + damage to the lymph nodes
- IV – Organ metastases (IVB)
Grade of malignancy:
- G1 (low) → G3 (high aggressiveness)
Key prognosis factors:
- Tumor size
- Lymph node involvement
- HPV/PD-L1 status
Diagnostics: colposcopy, MRI, PET-CT.
Treatment methods for cervical cancer
1. Organ-preserving operations (for stages IA-IB1)
- Radical trachelectomy (fertility preservation)
- Robot-assisted surgery Da Vinci
- Conization with cryotherapy (for pre-invasive cancer)
2. Combination therapy (stages IB2-III)
- Chemoradiation therapy (cisplatin + external beam irradiation)
- Brachytherapy with 3D planning
- Neoadjuvant chemotherapy (to shrink the tumor)
3. Immunotherapy of metastatic forms
- Pembrolizumab (for PD-L1+)
- Tisilelumab (in clinical trials)
Prevention and vaccination
- Vaccine Gardasil 9 (protection against 9 oncogenic types of HPV)
- Screening program:
- Up to 30 years: PAP test every 3 years
- After 30: PAP test + HPV typing every 5 years
- Rapid tests for HPV for home use
Survival prognosis
5-year survival by stage (FIGO 2018):
- Stage 0 (in situ): ~100%
- Stage I: 80-95%
- Stage II: 50-75%
- Stage III: 30-40%
- IV stage: 15-20%
Key prognosis factors:
- Early diagnosis (before cervical spread)
- No lymph node involvement
- Tumor size <4 cm
- Squamous cell type (better than adenocarcinoma)
- Possibility of radical treatment
Our clinics
The association of clinics RheinRegio Klinik Zentrum offers the organization of treatment for cervical cancer in Germany without intermediaries, providing access to the country’s leading oncology clinics. We combine advanced techniques, an individual approach and the highest level of medical care, giving hope even in difficult cases.
Why RheinRegio Klinik Zentrum?
- ESGO Center for HPV-Associated Tumors
- Clinical trials of new immunotherapeutic drugs
- Fertility preservation programs for young patients
- Robotic systems for gentle operations
