Treatment of angiosarcoma in Germany
Innovative methods of treating angiosarcoma: from molecular diagnostics to targeted treatment

Angiosarcoma is a rare but extremely aggressive malignant tumor that develops from cells of the blood or lymph vessels. It is characterized by rapid invasive growth and a high tendency to metastasize. The RheinRegio Klinik Zentrum uses innovative treatment methods, including targeted therapy, radiation therapy and surgical excision, which significantly improves the prognosis even in difficult cases.
Symptoms of angiosarcoma
- Purple, bluish or red spots/nodules (in the cutaneous form)
- Fast-growing tumor with jagged edges
- Pain, swelling, bleeding in the affected area
- Symptoms of organ compression (shortness of breath, jaundice, cardiac dysfunction)
- General weakness, anemia, weight loss (in later stages)
Because angiosarcoma is highly aggressive, early diagnosis is critical.
Diagnosis of angiosarcoma at RheinRegio Klinik Zentrum
RheinRegio Klinik Zentrum uses a comprehensive approach:
- Biopsy with immunohistochemistry (precise determination of tumor type).
- MRI and CT with contrast (prevalence assessment).
- PET-CT (search for metastases).
- Ultrasound, angiography, EchoCG (for vascular/heart damage).
Only highly accurate diagnostics allows you to choose effective treatment.
Each direction is supervised by advanced oncologists.
Find out the cost of treatment
To find out the approximate cost of treatment, answer a few questions and we will contact you!
Classification and stages of angiosarcoma
The classification is based on tumor size, depth of germination and the presence of metastases:
- Localized form – the tumor is limited to one anatomical zone.
- Regional spread – damage to the lymph nodes.
- Metastatic stage – distant metastases (lungs, liver, bones).
Histological types:
- Cutaneous angiosarcoma (more often in the elderly).
- Post-radiation (develops after radiation therapy).
- Idiopathic (without obvious causes).
Treatment methods for angiosarcoma
Our clinic uses modern protocols:
- Surgery – radical removal of the tumor with the capture of healthy tissue.
- Radiation therapy (IMRT, proton) – to reduce the risk of relapse.
- Chemotherapy (doxorubicin, taxanes) – for metastases.
- Targeted therapy (VEGF inhibitors, tyrosine kinases).
- Immunotherapy (PD-1/PD-L1 inhibitors) – within the framework of clinical trials.
Why RheinRegio Klinik Zentrum?

- World-class specialists with experience in treating rare sarcomas.
- The latest equipment for accurate diagnosis and gentle therapy.
- Individual schemes according to international standards (NCCN, ESMO).
- Support at all stages – from the first application to rehabilitation.












