Treatment of infiltrating carcinoma in Germany
Innovative methods for treating infiltrating carcinoma: from accurate diagnosis to targeted therapy

Infiltrating carcinoma is an aggressive form of cancer characterized by the ability of tumor cells to invade surrounding tissue. In Germany, innovative diagnostic protocols and combined treatment methods are used to combat this disease, allowing to achieve maximum effectiveness of therapy.
Symptoms of infiltrating carcinoma
The main types of infiltrating carcinoma are:
- Ductal (80% of cases) – develops from the milk ducts
- Lobular (10-15%) – occurs in the lobules of the gland
- Nonspecific type – rare aggressive forms
Alarming symptoms:
- Lump in the chest with uneven contours
- Retraction of the nipple or skin (“lemon peel”)
- Rapid increase in education
- Pain on palpation
- Enlarged axillary lymph nodes
Precision dDiagnosis of infiltrating carcinoma at RheinRegio Klinik Zentrum
- 3D contrast-enhanced mammography
- MRI of the mammary glands (sensitivity 95%)
- Ultrasound with elastography (assessment of tumor density)
- Biopsy with immunohistochemistry:
- Definition of ER/PR receptors
- HER2/neu status
- Index Ki-67
- PET-CT to detect metastases
Each direction is supervised by advanced oncologists.
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Treatment options for infiltrating carcinoma
1. Surgical approaches
- Organ-conserving surgeries (lumpectomy + radiation therapy)
- Mastectomy with simultaneous reconstruction
- Sentinel biopsy (low-traumatic assessment of lymph nodes)
2. Adjuvant therapy
- Neoadjuvant chemotherapy (shrinking the tumor before surgery)
- Targeted drugs (trastuzumab, pertuzumab for HER2+)
- Hormonal therapy (aromatase inhibitors for ER+)
- Immunotherapy (pembrolizumab for PD-L1+)
3. Modern irradiation technologies
- Intraoperative radiotherapy (IORT)
- 3D conformal irradiation
- Proton therapy (for complex cases)
Survival prognosis
5-year survival rate reaches:
- 90% at stage I
- 75% at stage II
- 45% at stage III
After treatment it is recommended:
- Quarterly examination by an oncologist
- Annual mammogram
- Tumor marker control
- Scanograms according to an individual schedule
Germany offers the most advanced methods of combating infiltrating carcinoma. At RheinRegio Klinik Zentrum, each patient receives an individual treatment program developed by a council of specialists.
To consult with German experts, leave a request on our website!
Why RheinRegio Klinik Zentrum?

- International protocols (NCCN, ESMO)
- Genetic testing (BRCA, PALB2)
- Cryopreservation of eggs before chemotherapy
- World-class reconstructive surgery
- Psychological support at all stages












