Treatment of ovarian carcinoma in Germany
Innovations in the treatment of ovarian carcinoma: from surgical debulking to PARP inhibitors
Ovarian carcinoma is an aggressive cancer that ranks 5th among the causes of cancer mortality in women. RheinRegio Klinik Zentrum uses advanced treatment protocols, including HIPEC cytoreductive surgeries, targeted therapy and individual chemotherapy regimens, which can significantly improve the prognosis even in advanced stages of the disease.
Symptoms of ovarian carcinoma
The early stages are often asymptomatic. Warning signs:
- Abdominal enlargement (ascites)
- Pelvic pain of unknown origin
- Disorders of urination and defecation
- Quick satiety when eating
- Unexplained weight loss
- Menstrual irregularities (in young women)
If these symptoms are present, an urgent gynecological examination is necessary.
Diagnosis of ovarian carcinoma at RheinRegio Klinik Zentrum
- Transvaginal ultrasound with Doppler ultrasound
- MRI of the pelvis with diffusion-weighted images
- CT scan of the abdomen with contrast
- Analysis for tumor markers (CA-125, HE4, ROMA index)
- Diagnostic laparoscopy with biopsy
- Genetic testing (BRCA, HRD status)
Each direction is supervised by advanced oncologists.
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Classification and stages of ovarian carcinoma
Main histological types:
- Serous (75-80%) – the most aggressive
- Endometrioid (10%)
- Mucinous (5%)
- Clear cell (5%)
FIGO staging:
- Stage I: limited to the ovaries
- Stage II: spread to the pelvis
- Stage III: peritoneal metastases
- Stage IV: distant metastases
Treatment options for ovarian carcinoma
Surgical treatment:
- Radical cytoreduction (optimal – residual tumor <1 cm)
- HIPEC (hyperthermic intraperitoneal chemotherapy)
- Lymphadenectomy of pelvic and para-aortic lymph nodes
Drug therapy:
- Neoadjuvant chemotherapy (carboplatin + paclitaxel)
- Targeted drugs (bevacizumab, olaparib)
- Immunotherapy (for MSI-H status)
Innovative approaches:
- Intraoperative radiotherapy
- Personalized schemes based on NGS testing
Survival prognosis
Ovarian carcinoma requires a comprehensive approach. At RheinRegio Klinik Zentrum we offer individual treatment programs based on the latest advances in gynecological oncology.
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Our clinics
The association of clinics RheinRegio Klinik Zentrum offers the organization of treatment of ovarian carcinoma in Germany without intermediaries, providing access to the country’s leading oncology clinics. We combine advanced techniques, an individual approach and the highest level of medical care, giving hope even in difficult cases.
Why RheinRegio Klinik Zentrum?
- Gynecological oncologists with experience >300 cytoreductive operations
- In-house molecular pathology laboratory
- Full range of HIPEC technologies
- Latest generation clinical trials
- Rehabilitation programs after treatment
