Treatment of sarcoma in Germany
Innovative approaches to the treatment of rare tumors: from organ-conserving surgeries to proton therapy
Sarcoma is a group of rare malignant tumors that develop from connective tissue (bones, muscles, adipose tissue). The RheinRegio Klinik Zentrum uses interdisciplinary protocols that combine radical tumor removal with preservation of limb function and modern rehabilitation methods.
Symptoms of sarcoma
General manifestations
- Painless soft tissue hardening (increases over time)
- Aching pain in the bones (intensified at night, not relieved by analgesics)
- Limitation of joint mobility
- Pathological fractures (with bone forms)
Localized symptoms
- Sarcomas of the extremities: asymmetry, venous pattern on the skin
- Retroperitoneal sarcomas: abdominal enlargement, constipation
- Chest sarcomas: shortness of breath, hemoptysis
Important: 70% of soft tissue saromas are mistaken for hematomas or lipomas.
Diagnosis of sarcoma at RheinRegio Klinik Zentrum
At RheinRegio Klinik Zentrum we carry out:
- MRI with contrast (gold standard for soft tissue sarcomas)
- CT scan of the chest (detection of micrometastases)
- 18F-FDG PET-CT (assessment of response to therapy)
- Trephine biopsy under CT control (minimal trauma)
- Molecular genetic tests:
- Translocation detection (SYT-SSX, EWSR1)
- Identification of targets for targeted therapy
Innovation: Liquid biopsy for monitoring relapses.
Each direction is supervised by advanced oncologists.
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Classification and stages of sarcoma
Main types
Bone sarcomas:
- Osteosarcoma (usually in the knee joint)
- Ewing’s sarcoma (in children and adolescents)
Soft tissue sarcomas:
- Liposarcoma
- Leiomyosarcoma
- Synovial sarcoma
Grade of malignancy (G)
- G1 (low) – slow growth
- G3 (high) – early metastasis
Stages according to the TNM system
- Stage I: Tumor ≤5 cm without metastases
- Stage III: Locally widespread process
- Stage IV: Metastases to the lungs and bones
Treatment methods for sarcoma
1. Surgical treatment
- Wide excision with 2-3 cm of healthy tissue
- Safe operations with joint replacement
- Reconstructive surgery (microsurgical plastic surgery)
2. Radiation therapy
- Proton therapy (for pediatric tumors)
- Intraoperative radiation therapy (IOERT)
3. Systemic therapy
- Neoadjuvant chemotherapy (doxorubicin + ifosfamide)
- Targeted drugs (pazopanib for angiosarcomas)
- Immunotherapy (trastuzumab for HER2+ sarcomas)
4. HIPEC therapy
- For sarcomatosis of the peritoneum
Survival prognosis
- Localized sarcomas: 60-80% 5-year survival rate
- Metastatic form: 10-15% (with complex treatment)
Factors for improving prognosis:
- Complete surgical response (R0)
- Sensitivity to chemotherapy
- Low grade
Why choose Germany?
- Leader in the treatment of rare tumors
- Access to clinical trials (phase I-II)
Conclusion
At RheinRegio Klinik Zentrum, individual protocols are used for each type of sarcoma. We combine radical treatment with maintaining quality of life.
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Our clinics
The association of clinics RheinRegio Klinik Zentrum offers the organization of sarcoma treatment in Germany without intermediaries, providing access to the country’s leading oncology clinics. We combine advanced techniques, an individual approach and the highest level of medical care, giving hope even in difficult cases.
Why RheinRegio Klinik Zentrum?
- Sarcoma Expertise Center – diagnosis according to ESMO criteria
- Organ-preserving technologies – 3D navigation during operations
- Proton therapy – treatment of tumors in children without long-term consequences
- Genetic passport of a tumor – selection of personalized therapy
- Rehabilitation – mobility restoration programs
