Treatment of ALL (acute lymphoblastic leukemia) in Germany
Modern therapy of acute lymphoblastic leukemia: from molecular diagnostics to personalized treatment
Acute lymphoblastic leukemia (ALL) is an aggressive malignant disease of the hematopoietic system, characterized by the uncontrolled proliferation of immature lymphoblasts. In Germany, modern chemotherapy protocols, targeted drugs and bone marrow transplantation are used, which allows achieving complete remission in 90% of children and 80% of adult patients
Symptoms of ALL (acute lymphoblastic leukemia)
Main symptoms:
- Anemic syndrome: weakness, pallor, dizziness
- Hemorrhagic syndrome: bleeding gums, nosebleeds
- Infectious complications: frequent pneumonia, stomatitis
- Lymphoproliferative syndrome: enlarged lymph nodes, liver, spleen
- Osteoarticular pain (especially in children)
Laboratory signs:
- Blast cells in peripheral blood (>20%)
- Thrombocytopenia, anemia
- Leukocytosis or leukopenia
Diagnosis of acute lymphoblastic leukemia at RheinRegio Klinik Zentrum
- Sternal puncture with cytochemical examination
- Immunophenotyping (determination of CD19, CD22, CD79a)
- Cytogenetic analysis (t(9;22), t(12;21), t(4;11))
- Molecular genetic tests (BCR-ABL1, MLL gene)
- Lumbar puncture (assessment of neuroleukemia)
- CT/MRI for suspected extramedullary lesions
Each direction is supervised by advanced oncologists.
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Treatment methods for acute lymphoblastic leukemia
1. Induction of remission
- Pediatric protocols (BFM, AIEOP)
- Adult circuits (Hyper-CVAD, CALGB)
- Targeted therapy (imatinib for Ph+ ALL)
2. Consolidation
- High-dose cytarabine and methotrexate
- Prevention of neuroleukemia (intrathecal chemotherapy)
3. Maintenance therapy
- Oral cytostatics (6-mercaptopurine, methotrexate)
- Immunotherapy (blinatumomab, CAR-T cells)
4. Bone marrow transplantation
- Allogeneic BMT with a high risk of relapse
- Haploidentical transplantation in the absence of a donor
Survival prognosis
5-year survival rate is:
- 90-95% in children
- 60-80% in adults
After treatment you must:
- Monthly blood checks
- Bone marrow taps every 3-6 months
- Lifelong observation by an oncohematologist
Germany offers the most effective treatments for ALL. The RheinRegio Klinik Zentrum uses all modern technologies, including access to clinical trials.
To consult with German specialists, leave a request on our website!
Our clinics
The association of clinics RheinRegio Klinik Zentrum offers the organization of lymphoma treatment in Germany without intermediaries, providing access to the country’s leading oncology clinics. We combine advanced techniques, an individual approach and the highest level of medical care, giving hope even in difficult cases.
Why RheinRegio Klinik Zentrum?
- International protocols (GMALL, COG)
- Genetic typing for personalized therapy
- Cell technologies (CAR-T therapy)
- Laminar flow rooms for infection protection
- Psychological support for patients and families
